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Toluene → (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Carboxymethylene triphenylphosphorane | HCID 10870911 | — |
| 反応物 | 5-Hydroxy-[1,1'-biphenyl]-2-carbaldehyde | HCID 57303464 | — |
| 生成物 | (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate | HCID 58566652 | — |
反応手順
A solution of 5-hydroxy-[1,1′-biphenyl]-2-carbaldehyde (651) (292 mg, 1.47 mmol) and (carboxymethylene)-triphenylphosphorane (564.5 mg, 1.62 mmol) in toluene (15 mL) was refluxed for 24 hours. The reaction was concentrated in vacuo and was purified by flash column chromatography on silica gel with hexanes and EtOAc (30%) to give (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08299117B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-73a19d5aa75645cda34aa78636ac221c |
| 出典メモ | uspto-grants-2012_10 |