Trifluoroacetic acid → 5-(Azetidin-3-yloxy)-2-bromo-pyridine trifluoro-acetic acid salt

Participants

Reaction Steps

To a solution of 3-(6-Bromo-pyridin-3-yloxy)-azetidine-1-carboxylic acid tert-butyl ester (1.08 g, 3.28 mmol) in DCM (30 mL), add TFA (10 mL). Let the mixture be stirred at room temperature for 2 hrs. LC-MS and TLC show reaction was complete. So evaporate all the solvent and excessive TFA. The residue brown solid 5-(Azetidin-3-yloxy)-2-bromo-pyridine trifluoro-acetic acid salt (1.06 g, 95% yield) was used directly for next step.

Provenance & Evidence