関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | 6-Fluoro-1,2,3,4-tetrahydroisoquinolin-1-one | HCID 10725709 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-(Dimethylamino)-3,4-dihydroisoquinolin-1(2H)-one | HCID 57424121 | — |
反応手順
6-Fluoro-3,4-dihydro-2H-isoquinolin-1-one (1.56 g, 9.45 mmol) was deposited in a sealed vessel with 25 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 7 hours. The resulting solution was partitioned between ethyl acetate and water. The ethyl acetate layer was washed with brine, dried over anhydrous magnesium sulfate, concentrated in vacuo, and purified by flash chromatography (elution with ethyl acetate) to yield 6-Dimethylamino-3,4-dihydro-2H-isoquinolin-1-one (787 mg, 4.14 mmol). MS (ESI) 191.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08299077B2 |
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| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-967910be29b240c1a2a473050288264b |
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| 出典メモ | uspto-grants-2012_10 |
|---|
