HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2069743Generated: October 25, 2026
Dimethylamine → 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one
https://huagongshe.com/reaction/2069743
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 6-Fluoroisoquinolin-1(2H)-one | HCID 45090802 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one | HCID 57424142 | — |
Reaction Steps
6-Fluoro-2H-isoquinolin-1-one (54 mg, 0.33 mmol) was deposited in a sealed tube with 5 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 3.5 hours. This was concentrated in vacuo and purified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes) to yield 6-Dimethylamino-2H-isoquinolin-1-one (39 mg, 0.21 mmol). MS (ESI) 189.1 (M+H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299077B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-45bdd3b449d544b8801d551331c06025 |
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| Source note | uspto-grants-2012_10 |
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