1,1'-Carbonyldiimidazole → HCID 59473790, compound

Participants

Reaction Steps

To a suspension of 4-Dimethylamino-2-fluoro-6-methyl-benzoic acid (0.896 g, 4.54 mmol) in THF (11 mL) was added carbonyldiimidazole (0.958 g, 5.91 mmol). The solution became homogeneous with bubbling. After 30 min., this solution was added to concentrated ammonium hydroxide (7 mL), and the solution became cloudy. Following removal of solvent after 1 h, the residue was taken up in H2O and filtered to give 4-dimethylamino-2-fluoro-6-methyl-benzamide as a white solid (0.696 g, 78%).

Provenance & Evidence