Citric Acid → HCID 59473759, compound

Participants

Reaction Steps

To the clear solution of 4-Dimethylamino-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methyl-benzamide (0.709 g, 2.82 mmol) in THF (2 mL) was added potassium tert-butoxide (2.8 mL, 1.0 M THF, 1.0 eq.), and the resultant brown, homogeneous reaction mixture was refluxed. After 1 h., the reaction mixture was quenched with 1M citric acid (1 eq.), dried (MgSO4), filtered, and concentrated in vacuo to give a yellow solid, which was purified by preparative plate (50% 60/10/1 CH2Cl2/MeOH/NH4OH in CH2Cl2) to give 6-Dimethylamino-8-fluoro-2H-isoquinolin-1-one as a white solid (0.104 g, 18%).

Provenance & Evidence