HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 4-tert-Butylbenzoyl chloride | HCID 74372 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide | HCID 320076 | 105.5% |
Reaction Steps
30.95 g (347 mmol) of 2-amino-2-methyl-1-propanol was weighed into a 500 mL Erlenmeyer flask fitted with a stir bar and septum. Added 200 mL CH2Cl2. Established and maintained nitrogen atmosphere. Stirred the solution in an ice/water bath. Added 34 mL (174 mmol) of 4-tert-butylbenzoyl chloride dropwise over 30 min. A white precipitate formed. Stirred at room temperature overnight. Removed the solids by filtration and washed with CH2Cl2. Removed the solvent from the filtrate on rotavap and dried at 60° C./4 torr to obtain 45.79 g of the title compound as a light yellow resin. MS (ESI) 248 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299077B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d380c838426545efa782f67f20769c25 |
| Source note | uspto-grants-2012_10 |