HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-bromobenzylcarbamate → Tert-butyl (5'-cyano-2'-methoxybiphenyl-3-ylmethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-bromobenzylcarbamate | HCID 11033439 | — |
| Reactant | 4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile | HCID 46739734 | — |
| Product | Tert-butyl (5'-cyano-2'-methoxybiphenyl-3-ylmethyl)carbamate | HCID 86607705 | 68% |
Reaction Steps
Proceeding as in Reference 19, but substituting tert-butyl(3-bromo-benzyl)-carbamate (0.9 g, 3.2 mmol) and 4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile (0.9 g, 3.5 mmol), gave tert-butyl(5′-cyano-2′-methoxybiphenyl-3-ylmethyl)carbamate (0.73 g, 68%) as white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299110B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a9240e7257b14c3dba3366289f6bc45e |
| Source note | uspto-grants-2012_10 |