Camptothecin → HCID 11024585, compound

Participants

Reaction Steps

In a 350 mL high pressure autoclave, 6 g (17.2 mmol) of camptothecin was suspended in 60 mL of acetic acid, and into which 1.2 g of stabilized nickel catalyst (N113) was added. After hydrogen substitution of the inside atmosphere, the suspension was heated at 110° C. under 2.0 MPa for 6 hours with stirring, whereat the starting material disappeared. The reaction liquid was cooled off to room temperature, filtered on 0.5 g of Celite and washed with 10 mL of acetic acid. An HPLC analysis of this solution confirmed that this Example could produce 1,2,6,7-tetrahydrocamptothecin at an yield of 97% (The diastereoisomeric ratio was 23:74).

Provenance & Evidence