Sodium borohydride → 3-(4-Nitro-2-(trifluoromethyl)phenyl)propan-1-ol

Participants

Reaction Steps

3-(4-Nitro-2-(trifluoromethyl)phenyl)propionaldehyde (1700 mg, 6.9 mmol) was dissolved in methanol (10 mL), and sodium borohydride (100 mg, 2.64 mmol) was added thereto. The mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and then purified by silica-gel column chromatography (n-hexane:ethyl acetate=3:1) to give 3-(4-nitro-2-(trifluoromethyl)phenyl)propan-1-ol (859 mg, 50%) as a light-yellow oil.

Provenance & Evidence