(Diethylamino)sulfur trifluoride → HCID 59398561, compound

Participants

Reaction Steps

[4-(2-Hydroxyethyl)-3-(trifluoromethyl)phenyl]carbamic acid benzyl ester (428 mg, 1.26 mmol) was dissolved in DCM (4 mL), and DAST (339 mL, 2.10 mmol) was added thereto. The resulting mixture was stirred for about 3 hours. The reaction solution was quenched with a saturated sodium bicarbonate solution, and then DCM (20 mL) was added thereto. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography (n-hexane:ethyl acetate=5:1) to give [4-(2-fluoroethyl)-3-(trifluoromethyl)phenyl]carbamic acid benzyl ester (194 mg, 45%) as a yellow oil.

Provenance & Evidence