(Diethylamino)sulfur trifluoride → HCID 59398570, compound

Participants

Reaction Steps

[4-(4-Hydroxybutyl)-3-trifluoromethylphenyl]carbamic acid tert-butyl ester (190 mg, 0.57 mmol) was dissolved in DCM (2 mL), and DAST (153 mg, 0.95 mmol) was added thereto. The resulting mixture was stirred at room temperature for 2 hours. The reaction solution was quenched with a saturated sodium bicarbonate solution. The organic layer was dried over sodium sulfate and then concentrated under reduced pressure. The residue was purified by silica-gel column chromatography (n-hexane:ethyl acetate=5:1) to give [4-(4-fluorobutyl)-3-trifluoromethylphenyl]carbamic acid tert-butyl ester (96 mg, 50%) as a light-yellow oil.

Provenance & Evidence