HCID 59398570, compound → HCID 59398578, compound

Participants

Reaction Conditions

Reaction Steps

[4-(4-Fluorobutyl)-3-trifluoromethylphenyl]carbamic acid tert-butyl ester (300 mg, 1.8 mmol) was dissolved in trifluoroacetic acid (1 mL). The mixture was stirred at room temperature for 40° C. The trifluoroacetic acid was removed by reducing the pressure. To the residue, a saturated sodium bicarbonate solution was added. The resulting mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate and then concentrated under reduced pressure to give 4-(4-fluorobutyl)-3-(trifluoromethyl)aniline (67 mg, 100%) as a light-yellow oil.

Provenance & Evidence