HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2070117Generated: November 1, 2026
Thionyl Chloride → Methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate
https://huagongshe.com/reaction/2070117
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate | HCID 53235501 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate | HCID 49850068 | — |
Reaction Steps
Methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate (26.7 g, 0.1 mol) was dissolved in 150 ml of CH2Cl2, and the solution was cooled to 5° C. SOCl2 (0.12 mol) in 30 ml of CH2Cl2 was slowly added dropwise at this temperature. The mixture was stirred at 40° C. for a further 4 h and concentrated under reduced pressure. The product can be used further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299260B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-e8093daad10e4390ac2add3568ca9900 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
