Phenol → 2-Phenoxy-4-(trifluoromethyl)pyrimidine

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-4-trifluoromethylpyrimidine (3.0 g, 0.016 mol) in DMF (30 ml) were successively added phenol (1.9 g, 20 mmol), potassium carbonate (3.3 g, 24 mmol) and Cu(I) (100 mg). The reaction mixture was stirred for 7 h at 90° C. The resulting reaction mixture was partitioned between MTBE and water. The aqueous layer was extracted with MTBE. The solvent was removed from the organic layers in vacuo. 2-Phenoxy-4-trifluoromethylpyrimidine was obtained as a yellowish solid (3.0 g). 1H-NMR (CDCl3): δ=7.2-7.5 (m, 6H); 8.7 ppm (m, 1H).

Provenance & Evidence