3,5-Dichlorosalicylaldehyde → HCID 86649074, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one (418 g) was dissolved in methanol (3.1 L), and 3,5-dichlorosalicylaldehyde (17.2 g) and D-(−)-tartaric acid (136 g) were added thereto, followed by stirring at 60° C. for 11 hours. The reaction mixture was left to stand to cool, and the formed precipitates were recovered through filtration. The thus-obtained solid was washed with methanol and dried, whereby the title compound (271 g) (97.8% ee) was yielded as a powdery compound.

Provenance & Evidence