D-Tartaric acid → HCID 86649075, compound

Participants

Reaction Steps

3-Amino-1-benzyl-8-(2-oxopyrrolidin-1-yl)-3,4-dihydroquinolin-2(1H)-one (1.0 g) was dissolved in a mixture of methanol and water (2:1) (20 mL), and D-(−)-tartaric acid (447 mg) was added thereto, followed by stirring at room temperature for two hours. The formed precipitates were recovered through filtration, washed with a mixture of methanol and water (2:1), and dried, whereby the title compound (587 mg) (98.5% ee) was yielded as a powdery compound.

Provenance & Evidence