反应详情

3-Amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one D-(−)-tartrate (254 g) was suspended in chloroform (1.3 L), and the suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L). The organic layers were combined, and the combined organic layer was dried over sodium sulfate. The solvent was evaporated, and ethyl acetate was added to the thus-recovered residue. The precipitates were recovered through filtration and dried, whereby the title compound (153 g) was yielded.

1. extractionthe suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L)
2. dry with materialthe combined organic layer was dried over sodium sulfate
3. customThe solvent was evaporated
4. additionethyl acetate was added to the thus-recovered residue
5. filtrationThe precipitates were recovered through filtration
6. customdried