HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-((tert-Butoxy)carbonyl)-D-tryptophan → (R)-2-(tert-butoxycarbonylamino)-3-(1-isopropyl-1H-indol-3-yl)propanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-((tert-Butoxy)carbonyl)-D-tryptophan | HCID 111050 | — |
| Reactant | Isopropyl tosylate | HCID 598985 | — |
| Product | (R)-2-(tert-butoxycarbonylamino)-3-(1-isopropyl-1H-indol-3-yl)propanoic Acid | HCID 59620335 | 43.3% |
Reaction Steps
The procedure of Referential Example 1(a) was repeated, except that N-tert-butoxycarbonyl-D-tryptophan (3.0 g) and isopropyl 4-methylbenzenesulfonate (3.17 g) were used, whereby the title compound (1.48 g) was yielded.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299255B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-8b8e39185fb5486e86a5e79829c2fec2 |
| Source note | uspto-grants-2012_10 |