HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one → HCID 59620389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one | HCID 59620330 | — |
| Reactant | HCID 59620388 | HCID 59620388 | — |
| Product | HCID 59620389 | HCID 59620389 | 73.7% |
Reaction Steps
The procedure of Example 14(a) was repeated, except that (−)-3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one (200 mg) and (R)-2-(tert-butoxycarbonylamino)-3-(1-ethyl-1H-indol-3-yl)propanoic acid (234 mg) synthesized in Referential Example 1(b) were used, whereby the title compound (283 mg) was yielded.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299255B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-740145f52c47408e9b839cb0e8b585a1 |
| Source note | uspto-grants-2012_10 |