N-((tert-Butoxy)carbonyl)-D-tryptophan → HCID 86649076, compound

Participants

Reaction Steps

The procedure of Example 14(a) was repeated, except that (−)-3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one (300 mg) and N-tert-butoxycarbonyl-D-tryptophan (294 mg) were used, whereby tert-butyl (2R)-3-(1H-indol-3-yl)-1-oxo-1-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino]propan-2-ylcarbamate was yielded. Subsequently, the procedure of Example 15(a) was repeated, except that the compound prepared as described above was used, whereby the title compound (438 mg) was yielded.

Provenance & Evidence