反应详情

tert-Butyl (2R)-1-[8-(4-chlorobutanamido)-2-oxo-1,2,3,4-tetrahydroquinolin-3-ylamino]-4-methyl-1-oxopentan-2-ylcarbamate (350 mg) was dissolved in N,N-dimethylformaldehyde (4.0 mL), and sodium hydride (34 mg) was added thereto under cooling on ice, followed by stirring for 1.5 hours. The resultant mixture was extracted with water and ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (325 mg) was yielded.

1. temperatureunder cooling on ice
2. extractionThe resultant mixture was extracted with water and ethyl acetate
3. washThe organic layer was washed with saturated aqueous sodium chloride solution
4. dry with materialdried over sodium sulfate
5. customThe solvent was evaporated under reduced pressure, whereby the title compound (325 mg)
6. customwas yielded