HRID2070154

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14284791

未命名化合物

结构：Cn1cc(C[C@@H](N)C(=O)NC2Cc3cccc(N4CCCC4=O)c3N(Cc3ccsc3)C2=O)c2ccccc21

HCID44193684

未命名化合物

PRODUCTS

生成物

结构：CC[C@@](C)(NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O

HCID59620374

未命名化合物

收率 89.4%

PROCEDURE

实验过程

The procedure of Example 14(a) was repeated, except that (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]propanamide obtained in Example 8(b) (5.4 g) and (R)-2-(tert-butoxycarbonylamino)-2-methylbutanoic acid (2.4 g) were used, whereby the title compound (6.6 g) was yielded.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4754de5e67a044ab8cc641201d5c3b47
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08299255B2
来源说明: uspto-grants-2012_10

反应 SMILES

[NH2:1][C@H:2]([CH2:29][C:30]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[N:32]([CH3:39])[CH:31]=1)[C:3]([NH:5][CH:6]1[CH2:15][C:14]2[C:9](=[C:10]([N:16]3[CH2:20][CH2:19][CH2:18][C:17]3=[O:21])[CH:11]=[CH:12][CH:13]=2)[N:8]([CH2:22][C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[C:7]1=[O:28])=[O:4].[C:40]([O:44][C:45]([NH:47][C@:48]([CH3:54])([CH2:52][CH3:53])[C:49](O)=[O:50])=[O:46])([CH3:43])([CH3:42])[CH3:41]>>[CH3:54][C@@:48]([NH:47][C:45](=[O:46])[O:44][C:40]([CH3:43])([CH3:42])[CH3:41])([CH2:52][CH3:53])[C:49]([NH:1][C@H:2]([CH2:29][C:30]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[N:32]([CH3:39])[CH:31]=1)[C:3](=[O:4])[NH:5][CH:6]1[CH2:15][C:14]2[C:9](=[C:10]([N:16]3[CH2:20][CH2:19][CH2:18][C:17]3=[O:21])[CH:11]=[CH:12][CH:13]=2)[N:8]([CH2:22][C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[C:7]1=[O:28])=[O:50]