Hydrochloric Acid → (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide hydrochloride

Participants

Reaction Conditions

Reaction Steps

(2R)-2-(2-Amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide (1.5 g) was dissolved in isopropyl acetate (68.5 mL), and 4N hydrochloric acid in ethyl acetate (0.95 mL) was added thereto. The mixture was stirred at 55° C. for one hour, and then left to stand to cool to room temperature. The formed precipitates were recovered through filtration, washed with isopropyl acetate, and dried under reduced pressure, whereby the title compound (1.47 g) was yielded.

Provenance & Evidence