HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-mandelic acid → (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide(S)-(+)-mandelate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-mandelic acid | HCID 439616 | — |
| Reactant | (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide | HCID 59620332 | — |
| Product | (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide(S)-(+)-mandelate | HCID 89723349 | 62.1% |
Reaction Steps
The procedure of Example 34(k) was repeated, except that (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide (33 mg) and (S)-(+)-mandelic acid (8.5 mg) were used, whereby the title compound (24 mg) was yielded.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299255B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-825e1979415f45c48e42563cd076bdc1 |
| Source note | uspto-grants-2012_10 |