Hydrochloric Acid → (2R)-2-amino-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide

Participants

Reaction Conditions

Reaction Steps

Concentrated hydrochloric acid (89.6 mL) was added to the tetrahydrofuran solution of tert-butyl (2R)-4-methyl-1-oxo-1-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino]pentan-2-ylcarbamate, and the mixture was stirred at an internal temperature of 48±2° C. for 30 minutes. The resultant mixture was neutralized with 25% aqueous sodium hydroxide solution (172 g) under cooling on an ice bath, and the organic layer was separated, whereby a solution of the title compound in tetrahydrofuran was yielded.

Provenance & Evidence