HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68587480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenol, 3-(1,1-dimethylethyl)- | HCID 11450 | — |
| Reactant | 1-Chloro-5-methyl-4-nitro-2-(trifluoromethyl)benzene | HCID 21017975 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68587480 | HCID 68587480 | 72% |
Reaction Steps
In 50 ml of N,N-dimethylformamide, 3.00 g (19.97 mmol) of 3-tertbutylphenol, 4.35 g (18.16 mmol) of 4-chloro-5-trifluoromethyl-2-methylnitrobenzene and 3.26 g (23.60 mmol) of potassium carbonate are heated at 50° C. for 15 min. The reaction solution is added to water and extracted repeatedly with dichloromethane, the extracts are dried over Na2SO4 and filtered and the solvent is removed under reduced pressure. The solid is washed with water and hexane and dried under reduced pressure. (6.6 g, purity 70.0%, yield 72.0%, log P (pH 2.3)=5.68).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299301B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-51a2b8c425b44971bcf466b0d7d814bf |
| Source note | uspto-grants-2012_10 |