Tert-butyl 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxylate → Tert-butyl4-[3-amino-4-(methylamino)phenoxy]pyridine-2-carboxylate

Participants

Reaction Steps

A solution of tert-butyl 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxylate (1 eq) and 10% palladium on carbon (0.1 eq) in methanol was stirred at room temperature and flushed with nitrogen. Hydrogen was flushed through the reaction for 1-2 hours or until the reaction was determined to be complete by HPLC. Nitrogen was flushed through the reaction for 15 minutes before the reaction was filtered through a celite pad. The celite pad was washed with excess methanol followed by concentration under reduced pressure to afford the product as a light yellow solid. MS: MH+=316.

Provenance & Evidence