HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Chloro-5-methoxy-1,3-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178488270 | HCID 178488270 | — |
| Product | 2-Chloro-5-methoxy-1,3-benzoxazole | HCID 11819712 | — |
Reaction Steps
The mixture containing 5-methoxybenzoxazole-2-thiol was heated in thionyl chloride with a drop of DMF. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated. Purification on a silica gel column gave 2-chloro-5-methoxybenzoxazole as a white solid. MS: MH+=184.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-11aa3e08527344558a7d83fdb08fdaa3 |
| Source note | uspto-grants-2012_10 |