HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidineethanamine → HCID 131725837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidineethanamine | HCID 27568 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-{[4-Bromo-3-fluorophenylamino)-1-methylbenzimidazol-5-yloxy)pyridine-2-carboxylic acid | HCID 86592201 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131725837 | HCID 131725837 | — |
Reaction Steps
To 4-(2-{[4-bromo-3-fluoropheylamino)-1-methylbenzimidazol-5-yloxy)pyridine-2-carboxylic acid (1 eq) in tetrahydrofuran was added 2-piperidylethylamine (2 eq), HBTU (2 eq) and N,N-diisopropylethylamine (4 eq) and stir at ambient temperature for 16 h. The mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was concentrated and preparative chromatography yielded [4-(2-{[4-bromo-3-fluorophenyl]amino-1-methylbenzimidazol-5-yloxy)(2-pyridyl)]-N-(2-piperidylethyl)-carboxamide. MS: MH+=567.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c296b3952dd342c9a022ee77255fffa9 |
| Source note | uspto-grants-2012_10 |