HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidineethanamine → HCID 131728154, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidineethanamine | HCID 27568 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-{[4-Chloro-3-(trifluoromethyl)phenylamino)-1-methylbenzimidazol-5-yloxy)pyridine-2-carboxylic acid | HCID 86593093 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131728154 | HCID 131728154 | — |
Reaction Steps
To 4-(2-{[4-chloro-3-(trifluoromethyl)phenylamino)-1-methylbenzimidazol-5-yloxy)pyridine-2-carboxylic acid (1 eq) in tetrahydrofuran was added 2-piperidylethylamine (2 eq), HBTU (2 eq) and N,N-diisopropylethylamine (4 eq) and stir at ambient temperature for 16 h. The mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was concentrated and preparative chromatography yielded [4-(2-{[4-chloro-3-trifluoromethylphenyl]amino-1-methylbenzimidazol-5-yloxy)(2-pyridyl)]-N-(2-piperidylethyl)carboxamide. MS: MH+=558.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-0047091dd1ed4d269c07881c4306368b |
| Source note | uspto-grants-2012_10 |