1-Methylpiperazine → n-Methyl {4-[1-methyl-2-({4-[(4-methylpiperazinyl)methyl]phenyl}carbonylamino)benzimidazol-5-yloxy](2-pyridyl)}carboxamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of [4-(2-{[4-(chloromethyl)phenyl]carbonylamino)-1-methylbenzimidazol-5-yloxy)(2-pyridyl)]-N-methylcarboxamide (1 eq) in tetrahydrofuran was added methylpiperazine (4 eq) and stirred at ambient temperature for 16 h. The reaction mixture was concentrated and purified on preparative chromatography to yield N-methyl{4-[1-methyl-2-({4-[(4methylpiperazinyl) methyl]phenyl}carbonylamino) benzimidazol-5-yloxy](2-pyridyl)}carboxamide. MS: MH+=512.

Herkunft & Nachweise