Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | N-Methylformamide | HCID 31254 | — |
| Reactant | Benzoic acid, 3-isothiocyanato- | HCID 75046 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzoic Acid | HCID 243 | — |
Reaction Steps
To 4-[3-amino-4-(methylamino) phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 3-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h and concentrated the solvent and purified on silica gel to yield 3-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299108B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-07c53af854d640e996e9238fa915662f |
|---|
| Source note | uspto-grants-2012_10 |
|---|
