HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N,N-dimethyl-5-nitropyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N,N-dimethyl-5-nitropyridin-2-amine | HCID 75707 | — |
Reaction Steps
2-Chloro-5-nitropyridine (1.0 eq) and dimethylamine (2 M in EtOH, 4.6 eq) in NMP were heated for 2 h at 100° C. The solution was then poured slowly into H2O. The filtrate that formed was filtered and dried to give 2-(dimethylamino)-5-nitropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-bb2e98f39ed54637b6573023ba24f033 |
| Source note | uspto-grants-2012_10 |