HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 5-Fluoro-2-nitroaniline | HCID 75399 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(4-Methylpiperazin-1-yl)-2-nitroaniline | HCID 2760034 | — |
Reaction Steps
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3d76ef646bdf40959be1e238f94b47a3 |
| Source note | uspto-grants-2012_10 |