HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 22040478, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine | HCID 22040816 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22040478 | HCID 22040478 | — |
Reaction Steps
A 50 mL round bottom flask was charged with a suspension of 1 (680 mg, 2.5 mmol), hydroxylamine HCl (191 mg, 2.75 mmol), and pyridine (0.25 mL, 3.0 mmol) in ethanol (10 mL) and stirred at RT overnight. Crude product concentrated and absorbed onto silica gel, then chromatographed using 97:3 CH2Cl2/MeOH to give 2 as an orange solid. LCMS m/z 289.2 (MH+), Rt 2.06 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299108B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-11138bcd3fa8473083d09f07d3740b6a |
| Source note | uspto-grants-2012_10 |