[2-(3-Nitrophenyl)ethyl]pyrrolidine → 3-[2-(Pyrrolidin-1-yl)ethyl]aniline

HRID 2070348Notes

Reaction equation

HRID 2070348 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[N:12]1([CH2:11][CH2:10][C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 1

HCID 54447505[2-(3-Nitrophenyl)ethyl]pyrrolidine

Product 1

HCID 219550223-[2-(Pyrrolidin-1-yl)ethyl]aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture containing [2-(3-nitrophenyl)ethyl]pyrrolidine in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 3-(2-pyrrolidinylethyl)phenylamine.

Sources & evidence

ORD record
ord-5b2bf35589e6453eb80f4c2ae9e31887
Source dataset
uspto-grants-2012_10
Patent number
US08299108B2

Reaction notes

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