HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2070351Generated: November 2, 2026
Isopropanol → 3-Bromo-4-(1-methylethoxy)benzenamine
https://huagongshe.com/reaction/2070351
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1-fluoro-4-nitrobenzene | HCID 69699 | — |
| Product | 3-Bromo-4-(1-methylethoxy)benzenamine | HCID 18782522 | — |
Reaction Steps
3-Bromo-4-fluoronitrobenzene (1.0 eq) was added to a stirring solution of potassium carbonate (2.0 eq) in isopropanol. The solution was heated for 4 days at 80° C. The solution was cooled and filtered through Celite and the plug washed with EtOAc. The organic layer is then washed with brine and water, dried over MgSO4, filtered and concentrated to yield the desired product. Rt=8.72 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299108B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-06d1206399a14ae1903d2d5c52b0b003 |
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| Source note | uspto-grants-2012_10 |
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