HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → Methyl 4-methyl-1H-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Methyl Crotonate | HCID 638132 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Methyl 4-methyl-1H-pyrrole-3-carboxylate | HCID 15274278 | — |
Reaction Steps
By a similar operation as in Reference Example 19 and using p-toluenesulfonylmethyl isocyanide (94.6 g), methyl crotonate (48.5 g) and potassium tert-butoxide (76.7 g), the title compound was obtained as a pale-yellow solid (yield 16.8 g, 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299261B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d6f2358a08b444ecab46b14495c977bf |
| Source note | uspto-grants-2012_10 |