HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| Reactant | 2-Chloropyrimidine-5-sulfonyl chloride | HCID 43244366 | — |
| Product | 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620758 | — |
Reaction Steps
By a reaction under similar conditions as in Reference Example 55 and using 5-phenyl-1H-pyrrole-3-carbaldehyde (342% mg), sodium hydride (60% in oil, 120 mg), 15-crown-5 (0.60 mL) and 2-chloro-5-pyrimidinesulfonyl chloride (554 mg), the title compound was obtained as a yellow solid (yield 390 mg, 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299261B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7d49f21870a747b5afc8722288350036 |
| Source note | uspto-grants-2012_10 |