反应详情

To a solution of 6-oxo-spiro[4.5]decane-7-carboxylic acid methyl ester (9.99 g) obtained in Step 2 in methanol (200 mL) was added platinum oxide (0.2 g) in an atmosphere of hydrogen (<0.3 Mpa) at room temperature overnight. Then, the reaction mixture was filtered through Celite and the filtrate was concentrated. After adding ethyl acetate (30 mL) and n-hexane (30 mL) to the residue, the resulting insolubles were filtered off. The filtrate was concentrated and then dried in vacuo to give 6-hydroxy-spiro[4.5]decane-7-carboxylic acid methyl ester (10.11 g).

1. filtrationThen, the reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated
3. additionAfter adding ethyl acetate (30 mL) and n-hexane (30 mL) to the residue
4. filtrationthe resulting insolubles were filtered off
5. concentrationThe filtrate was concentrated
6. customdried in vacuo