反应详情

To 4,4-dimethyl-3-pent-4-enyl-cyclohex-2-enol (810 mg) obtained in Step 3 was added formic acid (60 mL), followed by stirring the reaction mixture at room temperature for 2 hours and then at 50° C. for 3 hours. After cooling down to room temperature and adding water, the reaction mixture was extracted with chloroform. The organic layer was washed with water, dried and concentrated. The residue was reduced in the same condition as in Step 3 to give 11,11-dimethyl-spiro[5.5]undec-7-en-2-ol (340 mg).

1. waitat 50° C. for 3 hours
2. temperatureAfter cooling down to room temperature
3. extractionthe reaction mixture was extracted with chloroform
4. washThe organic layer was washed with water
5. customdried
6. concentrationconcentrated