Sodium Hydroxide → HCID 57771565, compound

Participants

Reaction Steps

To a solution of 11,11-dimethyl-spiro[5.5]undec-7-ene-2-carbaldehyde (195 mg) obtained in Step 7 in methanol (5 mL) was added sodium borohydride (55 mg) under ice-cooling, followed by stirring the reaction mixture under ice-cooling for 15 minutes. Then, after addition of 0.5N aqueous sodium hydroxide solution (10 mL), the reaction mixture was extracted with diethyl ether. The organic layer was washed with water, dried and concentrated. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate (volume ratio)=10:1 to 5:1) to give (11,11-dimethyl-spiro[5.5]undec-7-en-2-yl)-methanol (190 mg).

Provenance & Evidence