Potassium bisulfate → HCID 57771482, compound

Participants

Reaction Steps

(R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (R)-α-methylbenzylamine salt (40 g) obtained in Step 1 was suspended in ethyl acetate (300 mL)-saturated aqueous potassium hydrogen sulfate solution (30 mL). The suspension was vigorously stirred until it became a solution, followed by extraction of the reaction mixture with ethyl acetate twice. The organic layer was washed successively with water and saturated brine, dried and concentrated to give (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (25 g).

Provenance & Evidence