HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclooctanol, 1-ethynyl- → HCID 87082498, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclooctanol, 1-ethynyl- | HCID 123539 | — |
| Reactant | N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 57608426 | — |
| Product | HCID 87082498 | HCID 87082498 | — |
Reaction Steps
Sonogashira reaction of 25 with 1-ethynyl-cyclooctanol yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-(2-(1-hydroxycyclooctyl)ethynyl)phenyl)propyl)acetamide as yellow oil. Yield (0.54 g, 44%). This compound was used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299307B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3f330eb7aef54d799f9b2dbdda3dac3f |
| Source note | uspto-grants-2012_10 |