HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1,3-dichloro-2-ethynyl- → n-(3-(3-(2-(2,6-Dichlorophenyl)ethynyl)phenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1,3-dichloro-2-ethynyl- | HCID 22271730 | — |
| Reactant | N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 57608426 | — |
| Product | n-(3-(3-(2-(2,6-Dichlorophenyl)ethynyl)phenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 87082326 | — |
Reaction Steps
Sonogashira reaction of 25 with 1,3-dichloro-2-ethynyl-benzene gave N-(3-(3-(2-(2,6-dichlorophenyl)ethynyl)phenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide as dark brown oil. Yield (0.32 g, 37%). This compound could not be separated completely from the starting bromide and was used directly in the step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299307B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7f7f62e590264bab9b4ed93f3d8b1a92 |
| Source note | uspto-grants-2012_10 |