HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (R)-N-cyclopropyl-4-methyl-3-(3-(1-(2-(oxiran-2-ylmethoxy)phenyl)cyclopropylamino)-2-oxopyrazin-1(2H)-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2R)-2-oxiranylmethyl ester | HCID 146513 | — |
| Reactant | HCID 66688774 | HCID 66688774 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-N-cyclopropyl-4-methyl-3-(3-(1-(2-(oxiran-2-ylmethoxy)phenyl)cyclopropylamino)-2-oxopyrazin-1(2H)-yl)benzamide | HCID 86663253 | — |
Reaction Steps
Potassium carbonate (216 mg) and cesium fluoride (36.5 mg) were added to N-cyclopropyl-3-(3-(1-(2-hydroxyphenyl)cyclopropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide (Example 167d, 500 mg) in DMF (9 mL) and stirred for 1 h. (R)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (311 mg) was added and the reaction stirred for 3 days. The reaction mixture was used without isolation/purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299246B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e941a7e1d94f492595ebadbe8a504cf0 |
| Source note | uspto-grants-2012_10 |