HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-{[2-(Benzyloxy)ethyl]sulfanyl}phenyl)propan-2-amine → Methyl 3-[3-{[1-(2-{[2-(benzyloxy)ethyl]sulfanyl}phenyl)-1-methylethyl]amino}-5-bromo-2-oxopyrazin-1(2H)-yl]-5-fluoro-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-{[2-(Benzyloxy)ethyl]sulfanyl}phenyl)propan-2-amine | HCID 66689716 | — |
| Reactant | methyl 3-(3,5-dibromo-2-oxo-1(2H)-pyrazinyl)-5-fluoro-4-methylbenzoate | HCID 66689945 | — |
| Product | Methyl 3-[3-{[1-(2-{[2-(benzyloxy)ethyl]sulfanyl}phenyl)-1-methylethyl]amino}-5-bromo-2-oxopyrazin-1(2H)-yl]-5-fluoro-4-methylbenzoate | HCID 66689720 | — |
Reaction Steps
The subtitle compound was prepared using a similar method to Example 252h from methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-5-fluoro-4-methylbenzoate (Example 252g) and 2-(2-{[2-(benzyloxy)ethyl]sulfanyl}phenyl)propan-2-amine (Example 320c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299246B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ff53d3cd6a464965af732c727cb3f7aa |
| Source note | uspto-grants-2012_10 |