HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2Z)-3-(2-cyanophenyl)prop-2-enoic acid → 3-(2-Cyanophenyl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2Z)-3-(2-cyanophenyl)prop-2-enoic acid | HCID 1899166 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Cyanophenyl)propanoic acid | HCID 12398850 | 90.7% |
Reaction Steps
A slurry of (Z)-3-(2-cyanophenyl)acrylic acid (Example 323a, 4.75 g) in ethanol (50 mL) was added to 5% Palladium (0.292 g) in ethanol (50 mL) and hydrogenated under 2.0 bar hydrogen pressure for 2 h. The reaction mixture was filtered and the filtrate evaporated to dryness to afford the sub title compound as a solid (4.36 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299246B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a001d97a0f734b7f966d398a04be9278 |
| Source note | uspto-grants-2012_10 |