HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2070842Generated: November 2, 2026
Hydrochloric Acid → (2R,3R)-3-Amino-2-methyl-3-phenylpropan-1-ol
https://huagongshe.com/reaction/2070842
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[(1R,2R)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methyl-1-phenylpropyl]-2-methylpropane-2-sulfinamide | HCID 66688903 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R,3R)-3-Amino-2-methyl-3-phenylpropan-1-ol | HCID 12452700 | 98.9% |
Reaction Steps
N-[(1R,2R)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methyl-1-phenylpropyl]-2-methylpropane-2-sulfinamide (Example 136b, 1.46 g) was stirred in methanol (10 mL) and then Hydrogen chloride (4M in dioxane) (10 mL) added. The reaction was stirred at 70° C. for 7 h and then concentrated in vacuo. The crude product was azeotroped with toluene then triturated in ether for 2 days after which the solvent was concentrated in vacuo to give the subtitle compound (0.47 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08299246B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-d1ef85c4437a41ecb83ea0770d2901c6 |
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| Source note | uspto-grants-2012_10 |
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